Publications

Berchuck JE, Baca SC, McClure HM, Korthauer K, Tsai HK, Nuzzo PVitale, Kelleher KM, He M, Steinharter JA, Zacharia S et al..  2022.  Detecting Neuroendocrine Prostate Cancer Through Tissue-Informed Cell-Free DNA Methylation Analysis.. Clin Cancer Res. 28(5):928-938.

Mosquera MJ, Kim S, Bareja R, Fang Z, Cai S, Pan H, Asad M, Martin MLaura, Sigouros M, Rowdo FM et al..  2022.  Extracellular Matrix in Synthetic Hydrogel-Based Prostate Cancer Organoids Regulate Therapeutic Response to EZH2 and DRD2 Inhibitors.. Adv Mater. 34(2):e2100096.

Jang J-Y, Hwang I, Pan H, Yao J, Alinari L, Imada E, Zanettini C, Kluk MJ, Wang Y, Lee Y et al..  2022.  A FOXO1-dependent transcription network is a targetable vulnerability of mantle cell lymphomas.. J Clin Invest. 132(24)

Jacobsen JOB, Baudis M, Baynam GS, Beckmann JS, Beltran S, Buske OJ, Callahan TJ, Chute CG, Courtot M, Danis D et al..  2022.  The GA4GH Phenopacket schema defines a computable representation of clinical data.. Nat Biotechnol. 40(6):817-820.

Xu X, Wang K, Vera O, Verma A, Jasani N, Bok I, Elemento O, Du D, Yu X, Karreth FA.  2022.  Gain of Chromosome 1q Perturbs a Competitive Endogenous RNA Network to Promote Melanoma Metastasis.. Cancer Res. 82(17):3016-3031.

Tang CP, Clark O, Ferrarone JR, Campos C, Lalani AS, Chodera JD, Intlekofer AM, Elemento O, Mellinghoff IK.  2022.  GCN2 kinase activation by ATP-competitive kinase inhibitors.. Nat Chem Biol. 18(2):207-215.

Kulm S, Langhans MT, Shen TS, Kolin DA, Elemento O, Rodeo SA.  2022.  Genome-Wide Association Study of Adhesive Capsulitis Suggests Significant Genetic Risk Factors.. J Bone Joint Surg Am. 104(21):1869-1876.

van der Mijn JC, Eng KW, Chandra P, Fernandez E, Ramazanoglu S, Sigaras A, Oromendia C, Gudas LJ, Tagawa ST, Nanus DM et al..  2022.  The genomic landscape of metastatic clear cell renal cell carcinoma after systemic therapy.. Mol Oncol. 16(12):2384-2395.

Altorki NK, Borczuk AC, Harrison S, Groner LK, Bhinder B, Mittal V, Elemento O, McGraw TE.  2022.  Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma.. Cell Rep. 39(1):110639.

DiNapoli SE, Martinez-McFaline R, Shen H, Doane AS, Perez AR, Verma A, Simon A, Nelson I, Balgobin CA, Bourque CT et al..  2022.  Histone 3 Methyltransferases Alter Melanoma Initiation and Progression Through Discrete Mechanisms.. Front Cell Dev Biol. 10:814216.

Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin T-Y, Liberatore KM, Bulaon DK et al..  2022.  Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.. Sci Signal. 15(757):eabm0808.

Cuppen E, Elemento O, Rosenquist R, Nikic S, IJzerman M, Zaleski IDurand, Frederix G, Levin L-Å, Mullighan CG, Buettner R et al..  2022.  Implementation of Whole-Genome and Transcriptome Sequencing Into Clinical Cancer Care.. JCO Precis Oncol. 6:e2200245.

Argueta LB, Lacko LA, Bram Y, Tada T, Carrau L, Rendeiro AFigueiredo, Zhang T, Uhl S, Lubor BC, Chandar V et al..  2022.  Inflammatory responses in the placenta upon SARS-CoV-2 infection late in pregnancy.. iScience. 25(5):104223.

Raman R, Villefranc JA, Ullmann TM, Thiesmeyer J, Anelli V, Yao J, Hurley JR, Pauli C, Bareja R, Eng KWha et al..  2022.  Inhibition of FGF receptor blocks adaptive resistance to RET inhibition in CCDC6-RET-rearranged thyroid cancer.. J Exp Med. 219(6)

He Y, Kim I-K, Bian J, Polyzos A, Di Giammartino DCampigli, Zhang Y-W, Luo J, Hernandez MO, Kedei N, Cam M et al..  2022.  A Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.. J Thorac Oncol. 17(12):1375-1386.

Linares JF, Cid-Diaz T, Duran A, Osrodek M, Martinez-Ordoñez A, Reina-Campos M, Kuo H-H, Elemento O, M Martin L, Cordes T et al..  2022.  The lactate-NAD axis activates cancer-associated fibroblasts by downregulating p62.. Cell Rep. 39(6):110792.

Greenberg J, Limberg J, Verma A, Kim D, Chen X, Lee YJ, Moore MD, Ullmann TM, Thiesmeyer JW, Loewenstein Z et al..  2022.  Metastatic pancreatic neuroendocrine tumors feature elevated T cell infiltration.. JCI Insight. 7(23)

Ertl IE, Lemberger U, Ilijazi D, Hassler MR, Bruchbacher A, Brettner R, Kronabitter H, Gutmann M, Vician P, Zeitler G et al..  2022.  Molecular and Pharmacological Bladder Cancer Therapy Screening: Discovery of Clofarabine as a Highly Active Compound.. Eur Urol. 82(3):261-270.

Matrai CE, Ohara K, Eng KWha, Glynn SM, Chandra P, Chatterjee-Paer S, Motanagh S, Mirabelli S, Kurtis B, He B et al..  2022.  Molecular Evaluation of Low-grade Low-stage Endometrial Cancer With and Without Recurrence.. Int J Gynecol Pathol. 41(3):207-219.

Podaza E, Kuo H-H, Nguyen J, Elemento O, M Martin L.  2022.  Next generation patient derived tumor organoids.. Transl Res. 250:84-97.

Hu Y, Bloy N, Elemento O, Buqué A.  2022.  Nicotinamide drives T cell activation in the mammary tumor microenvironment.. J Transl Med. 20(1):251.

Drozdz MM, Doane AS, Alkallas R, Desman G, Bareja R, Reilly M, Bang J, Yusupova M, You J, Eraslan Z et al..  2022.  A nuclear cAMP microdomain suppresses tumor growth by Hippo pathway inactivation.. Cell Rep. 40(13):111412.

Rendeiro AF, Ravichandran H, Kim J, Borczuk AC, Elemento O, Schwartz RE.  2022.  Persistent alveolar type 2 dysfunction and lung structural derangement in post-acute COVID-19.. medRxiv.

Ullmann TM, Thiesmeyer JW, Lee YJoo, Beg S, Mosquera JMiguel, Elemento O, Fahey TJ, Scognamiglio T, Houvras Y.  2022.  RET Fusion-Positive Papillary Thyroid Cancers are Associated with a More Aggressive Phenotype.. Ann Surg Oncol.

Laurent P, Yang C, Rendeiro AF, Nilsson-Payant BE, Carrau L, Chandar V, Bram Y, tenOever BR, Elemento O, Ivashkiv LB et al..  2022.  Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19.. Sci Immunol. 7(75):eadd4906.