Publications

Kuo H-H, Bhinder B, Gokozan HN, Gorski K, Chandra P, Manohar J, Guevara D, Otilano J, Moyer J, Tranquille M et al..  2026.  Patient-derived organoids across cancers reveal conserved tumor heterogeneity and actionable therapeutic vulnerabilities.. Sci Adv. 12(26):eadz3351.

De Boni L, Claridge S, Nath S, Tofani K, Stein BD, Park E, Steiner S, Elemento O, Pauli C, Hopkins BD.  2026.  Placing purines in precision medicine: Targeting a metabolic reliance in KRAS-mutant tumors.. iScience. 29(3):114954.

Du W, De Boni L, Hopkins BDavid, Elemento O.  2026.  A quantitative approach for defining the degradability landscape of protein degraders.. Nat Commun.

Duren-Lubanski A, Podaza E, Merrit E, Tocheva AS, M Martin L, Elemento O, Hopkins BD.  2026.  A Real-Time Image-Based Co-Culture Assay to Quantify Tumor-Infiltrating Lymphocyte-Mediated Apoptotic Killing of Patient-Derived Tumor Organoids.. J Vis Exp. (235)

Hanif SZ, Kutz C, Au CMCherie, Torregroza I, Palikhe S, Jannath SY, Fabiha T, Bhinder B, Washburn MP, Devost D et al..  2026.  Role of orphan G protein-coupled receptor GPR52 in breast cancer cell multicellular organization and collective invasion.. Br J Cancer.

Brieno-Enriquez M, Martinez-Marchal A, Choi E, Levy A, Chu T, Shivkumar S, Bochter J, Morales J, Walsh P, Martin-Ruiz M et al..  2026.  SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis.. Res Sq.

Pourbaghi M, Elemento O, Bradbury MS.  2026.  Scaffold-Constrained Generative Design Overcomes Failure Modes in Computational Protein Engineering.. bioRxiv.

Gilani A, Stein BD, Hoffmann A, de Lima RPereira, Ha EE, Homan EA, Ma L, Rubio-Navarro A, Wun TTha Ra, Carrascal GJose Ayala et al..  2026.  Secretory kinase FAM20C triggers adipocyte dysfunction, inciting insulin resistance and inflammation in obesity.. J Clin Invest. 136(1)

Nazzaro M, Mardis ER, Canella A, Bhinder B, Elemento O, Behbehani G, Currier M, Glaspell A, Lee DA, Cripe TP et al..  2026.  Trabectedin decreases myeloid resistance to improve the efficacy of anti-PD1 immunotherapy and delay glioma malignant progression.. Mol Ther Oncol. 34(1):201147.

Elemento O, Giannakakou P.  2026.  Training the Next Generation of AI-Enabled Cancer Scientists.. Cancer Discov. :OF1-OF4.

Roshal M, Kong IY, Dinalankara W, Reichel JB, Teater M, Binder B, Zairis S, Brody JD, Park SI, Kovach AE et al..  2026.  Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Sternberg cells reveals escape from NK cell recognition and an unfolded protein response.. Blood Cancer J.

Podaza E, Capuano J, Kuo H-H, Assaad MAl, Markowitz G, M Revuelta V, Nguyen J, Irizarry A, Ravichandran H, Ackermann S et al..  2026.  Tumor immune microenvironment reconstitution in patient-derived organoids enables therapy modeling for NSCLC.. Cell Rep Methods. :101339.

Purkayastha S, Park J, Beyer S, Chandra A, Markowitz SM, Lerman BB, Elemento O, Krumsiek J, Lo JC, Cheung JW.  2026.  Utilization of Serum Metabolomics and Polygenic Risk Scores in a Novel Risk Stratification Tool for the Prediction of Incident Atrial Fibrillation.. Circ Arrhythm Electrophysiol. :e013858.

Dantas E, Hootman KC, Moyer J, Tomberlin M, Curran K, Ramesh B, Price H, Kim J, McPherson AC, Hurd MA et al..  2026.  Very low-carbohydrate ketogenic diet in treatment-naïve women with endometrial cancer and overweight: a randomized feasibility study.. Nat Commun.

Assaad MAl, Hadi K, Levine MF, Guevara D, Patel M, Tranquille M, King A, Otilano J, Semaan A, Gundem G et al..  2026.  Whole genome sequencing approach to assess homologous recombination deficiency in a pan-cancer cohort.. Commun Med (Lond). 6(1):5.

Kozan ENur, de la Mora JDelgado-, Assaad MAl, Ginter P, Gundem G, Levine MF, Gorski K, Phan A, Beg S, Sigaras A et al..  2026.  Whole genome sequencing of locally advanced and metastatic breast carcinoma unravels relevant molecular signatures and novel events.. Pathol Res Pract. 282:156469.

Yoffe L, Bhinder B, Kang SWook, Zhang H, Singh A, Ravichandran H, Markowitz G, Martin M, Kim J, Zhang C et al..  2025.  Acquisition of discrete immune suppressive barriers contributes to the initiation and progression of preinvasive to invasive human lung cancer.. bioRxiv.

Setzen SA, Andreadis K, Elemento O, Rameau A.  2025.  AI-Powered Laryngoscopy: Exploring the Future With Google Gemini.. Laryngoscope. 135(6):1851-1853.

Bose A, Liu W, Yoo P, Sami A, Boniecki MT, Deshpande M, Osman M, Nguyen D, Castillo UD, Giannakakou P et al..  2025.  APOBEC3A-Induced DNA Damage Drives Polymerase θ Dependency and Synthetic Lethality in Cancer.. bioRxiv.

Nazha A, Elemento O, Ahuja S, Lam B, Miles M, Shouval R, McWeeney S, Sirhan S, Srisuwananukorn A, Haferlach T.  2025.  Artificial intelligence in hematology.. Blood. 146(19):2283-2292.

Moothedan E, Boyer M, Watts S, Abdel-Aty Y, Ghosh S, Rameau A, Sigaras A, Elemento O, Bensoussan Y.  2025.  The Bridge2AI-voice application: initial feasibility study of voice data acquisition through mobile health.. Front Digit Health. 7:1514971.

Razavian N, Batchu-Green P, Chowdhry V, Elemento O, Rajpurkar P, Saria S, Shah NH, Topol EJ.  2025.  Catalyzing Health AI by Fixing Payment Systems.. NEJM AI. 2(12)

Nauseef JT, Chu TR, Hooper WF, Alonso A, Oku A, Geiger H, Goldstein ZR, Shah M, Sigouros M, Manohar J et al..  2025.  A complex phylogeny of lineage plasticity in metastatic castration resistant prostate cancer.. NPJ Precis Oncol. 9(1):91.

de la Mora JDelgado-, Assaad MAl, Karaaslan S, Hadi K, Halima A, Deshpande A, Manohar J, Sigouros M, Medina-Martínez JS, Lieberman MD et al..  2025.  Corrigendum to "Whole genome and transcriptome analysis of pancreatic acinar cell carcinoma elucidates mechanisms of homologous recombination deficiency and unravels novel relevant fusion events" [Pathol. - Res. Pract. 266 (2025) 155798].. Pathol Res Pract. 266:155825.

Kim YE, Dobko M, Li H, Shao T, Periyakoil P, Tipton C, Colasacco C, Serpedin A, Elemento O, Sabuncu M et al..  2025.  A Deep-Learning Model for Multi-class Audio Classification of Vocal Fold Pathologies in Office Stroboscopy.. Laryngoscope. 135(7):2428-2436.