Publications

Altorki NK, Walsh ZH, Melms JC, Port JL, Lee BE, Nasar A, Spinelli C, Caprio L, Rogava M, Ho P et al..  2023.  Neoadjuvant durvalumab plus radiation versus durvalumab alone in stages I-III non-small cell lung cancer: survival outcomes and molecular correlates of a randomized phase II trial.. Nat Commun. 14(1):8435.

Barnes J, Brendel M, Gao VR, Rajendran S, Kim J, Li Q, Malmsten JE, Sierra JT, Zisimopoulos P, Sigaras A et al..  2023.  A non-invasive artificial intelligence approach for the prediction of human blastocyst ploidy: a retrospective model development and validation study.. Lancet Digit Health. 5(1):e28-e40.

Bhardwaj P, Iyengar NM, Zahid H, Carter KM, Byun DJun, Choi MHo, Sun Q, Savenkov O, Louka C, Liu C et al..  2023.  Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in .. Sci Transl Med. 15(684):eade1857.

Rowdo FPMadorsky, Xiao G, Khramtsova GF, Nguyen J, Olopade OI, Martini R, Stonaker B, Boateng R, Oppong JK, Adjei EK et al..  2023.  Patient-derived tumor organoids with p53 mutations, and not wild-type p53, are sensitive to synergistic combination PARP inhibitor treatment.. bioRxiv.

Kandola MS, Kulm S, Kim LK, Markowitz SM, Liu CF, Thomas G, Ip JE, Lerman BB, Elemento O, Cheung JW.  2023.  Population-Level Prevalence of Rare Variants Associated With Atrial Fibrillation and its Impact on Patient Outcomes.. JACC Clin Electrophysiol. 9(7 Pt 2):1137-1146.

Charilaou P, Mohapatra S, Doukas S, Kohli M, Radadiya D, Devani K, Broder A, Elemento O, Lukin DJ, Battat R.  2023.  Predicting inpatient mortality in patients with inflammatory bowel disease: A machine learning approach.. J Gastroenterol Hepatol. 38(2):241-250.

Brown-Burke F, Hwang I, Sloan S, Hinterschied C, Helmig-Mason JB, Long M, Chan WKeung, Prouty A, Chung J-H, Zhang Y et al..  2023.  PRMT5 inhibition drives therapeutic vulnerability to combination treatment with BCL-2 inhibition in mantle cell lymphoma.. Blood Adv. 7(20):6211-6224.

Sloan SL, Brown F, Long M, Weigel C, Koirala S, Chung J-H, Pray B, Villagomez L, Hinterschied C, Sircar A et al..  2023.  PRMT5 supports multiple oncogenic pathways in mantle cell lymphoma.. Blood. 142(10):887-902.

Ha ET, Taylor KD, Raffield LM, Briggs M, Yee A, Elemento O, Parikh M, Peterson SJ, Frishman W, Gerszten RE et al..  2023.  The Relationship of Duffy Gene Polymorphism, High Sensitivity C-Reactive Protein, and Long-term Outcomes.. medRxiv.

Falvo DJ, Grimont A, Zumbo P, Fall WB, Yang JL, Osterhoudt A, Pan G, Rendeiro AF, Meng Y, Wilkinson JE et al..  2023.  A reversible epigenetic memory of inflammatory injury controls lineage plasticity and tumor initiation in the mouse pancreas.. Dev Cell. 58(24):2959-2973.e7.

Rajendran S, Hu Y, Canella A, Peterson C, Gross A, Cam M, Nazzaro M, Haffey A, Serin-Harmanci A, Distefano R et al..  2023.  Single-cell RNA sequencing reveals immunosuppressive myeloid cell diversity during malignant progression in a murine model of glioma.. Cell Rep. 42(3):112197.

You J, Reilly MD, Eljalby M, Bareja R, Yusupova M, Vyas NS, Bang J, Ding W, Desman G, Miller LS et al..  2023.  Soluble adenylyl cyclase contributes to imiquimod-mediated inflammation and is a potential therapeutic target in psoriasis.. Exp Dermatol. 32(7):1051-1062.

Luo Y, Yamada M, N'Tumba-Byn T, Asif H, Gao M, Hu Y, Marangoni P, Liu Y, Evans T, Rafii S et al..  2023.  SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†.. Biol Reprod. 109(4):533-551.

Dantas E, Murthy A, Ahmed T, Ahmed M, Ramsamooj S, Hurd MA, Lam T, Malbari M, Agrusa C, Elemento O et al..  2023.  TIMP1 is an early biomarker for detection and prognosis of lung cancer.. Clin Transl Med. 13(10):e1391.

Crowley MJP, Bhinder B, Markowitz GJ, Martin M, Verma A, Sandoval TA, Chae C-S, Yomtoubian S, Hu Y, Chopra S et al..  2023.  Tumor-intrinsic IRE1α signaling controls protective immunity in lung cancer.. Nat Commun. 14(1):120.

Rustam S, Hu Y, Mahjour SBabak, Rendeiro AF, Ravichandran H, Urso A, D'Ovidio F, Martinez FJ, Altorki NK, Richmond B et al..  2023.  A Unique Cellular Organization of Human Distal Airways and Its Disarray in Chronic Obstructive Pulmonary Disease.. Am J Respir Crit Care Med. 207(9):1171-1182.

Wickersham M, Bartelo N, Kulm S, Liu Y, Zhang Y, Elemento O.  2023.  USING MACHINE LEARNING METHODS TO ASSESS THE RISK OF ALCOHOL MISUSE IN OLDER ADULTS.. Res Sq.

Wood WA, Dilip D, Derkach A, Grover NS, Elemento O, Levine R, Thanarajasingam G, Batsis JA, Bailey C, Kannappan A et al..  2023.  Wearable sensor-based performance status assessment in cancer: A pilot multicenter study from the Alliance for Clinical Trials in Oncology (A19_Pilot2).. PLOS Digit Health. 2(1):e0000178.

Mendelson NL, Assaad MAl, Hadi K, Manohar J, Sigouros M, Sboner A, Medina-Martínez JS, Elemento O, Jessurun J, Mosquera JMiguel.  2023.  Whole-genome Analysis Elucidates Complex Genomic Events in GLI1 -rearranged Enteric Tumor.. Am J Surg Pathol. 47(10):1192-1193.

Jaiswal A, Verma A, Dannenfelser R, Melssen M, Tirosh I, Izar B, Kim T-G, Nirschl CJ, K Devi SP, Olson WC et al..  2022.  An activation to memory differentiation trajectory of tumor-infiltrating lymphocytes informs metastatic melanoma outcomes.. Cancer Cell. 40(5):524-544.e5.

Martini R, Delpe P, Chu TR, Arora K, Lord B, Verma A, Bedi D, Karanam B, Elhussin I, Chen Y et al..  2022.  African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent.. Cancer Discov. 12(11):2530-2551.

Ciani Y, Fedrizzi T, Prandi D, Lorenzin F, Locallo A, Gasperini P, Franceschini GMarco, Benelli M, Elemento O, Fava LL et al..  2022.  Allele-specific genomic data elucidate the role of somatic gain and copy-number neutral loss of heterozygosity in cancer.. Cell Syst. 13(2):183-193.e7.

Doane AS, Elemento O.  2022.  Alterations in transcriptional networks in cancer: the role of noncoding somatic driver mutations.. Curr Opin Genet Dev. 75:101919.

Meggendorfer M, Jobanputra V, Wrzeszczynski KO, Roepman P, de Bruijn E, Cuppen E, Buttner R, Caldas C, Grimmond S, Mullighan CG et al..  2022.  Analytical demands to use whole-genome sequencing in precision oncology.. Semin Cancer Biol. 84:16-22.

Brendel M, Su C, Bai Z, Zhang H, Elemento O, Wang F.  2022.  Application of Deep Learning on Single-cell RNA Sequencing Data Analysis: A Review.. Genomics Proteomics Bioinformatics. 20(5):814-835.