Regulatory elements in molecular networks.

TitleRegulatory elements in molecular networks.
Publication TypeJournal Article
Year of Publication2017
AuthorsDoane AS, Elemento O
JournalWiley Interdiscip Rev Syst Biol Med
Date Published2017 05
KeywordsGene Regulatory Networks, Genome, Humans, Neoplasms, Quantitative Trait Loci, Regulatory Elements, Transcriptional, Transcription Factors

Regulatory elements determine the connectivity of molecular networks and mediate a variety of regulatory processes ranging from DNA looping to transcriptional, posttranscriptional, and posttranslational regulation. This review highlights our current understanding of the different types of regulatory elements found in molecular networks with a focus on DNA regulatory elements. We highlight technical advances and current challenges for the mapping of regulatory elements at the genome-wide scale, and describe new computational methods to uncover these elements via reconstructing regulatory networks from large genomic datasets. WIREs Syst Biol Med 2017, 9:e1374. doi: 10.1002/wsbm.1374 For further resources related to this article, please visit the WIREs website.

Alternate JournalWiley Interdiscip Rev Syst Biol Med
PubMed ID28093886
PubMed Central IDPMC5400678
Grant ListR01 CA194547 / CA / NCI NIH HHS / United States
U24 CA210989 / CA / NCI NIH HHS / United States