Publications

Giannopoulou EG, Elemento O.  2013.  Inferring chromatin-bound protein complexes from genome-wide binding assays.. Genome Res. 23(8):1295-306.

Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, Karoly ED, Mohney R, Stiles BM, Elemento O, Altorki NK et al..  2013.  Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.. Mol Cancer Res. 11(6):579-92.

Nolan DJ, Ginsberg M, Israely E, Palikuqi B, Poulos MG, James D, Ding B-S, Schachterle W, Liu Y, Rosenwaks Z et al..  2013.  Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration.. Dev Cell. 26(2):204-19.

Chang C-Y, H Pasolli A, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E.  2013.  NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.. Nature. 495(7439):98-102.

Lu Y, T Soong D, Elemento O.  2013.  A novel approach for characterizing microsatellite instability in cancer cells.. PLoS One. 8(5):e63056.

Baca SC, Prandi D, Lawrence MS, Mosquera JMiguel, Romanel A, Drier Y, Park K, Kitabayashi N, MacDonald TY, Ghandi M et al..  2013.  Punctuated evolution of prostate cancer genomes.. Cell. 153(3):666-77.

Sun X-J, Wang Z, Wang L, Jiang Y, Kost N, T Soong D, Chen W-Y, Tang Z, Nakadai T, Elemento O et al..  2013.  A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.. Nature. 500(7460):93-7.

Qiao Y, Giannopoulou EG, Chan CHin, Park S-H, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB.  2013.  Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.. Immunity. 39(3):454-69.

Israely E, Ginsberg M, Nolan D, Ding B-S, James D, Elemento O, Rafii S, Rabbany SY.  2014.  Akt suppression of TGFβ signaling contributes to the maintenance of vascular identity in embryonic stem cell-derived endothelial cells.. Stem Cells. 32(1):177-90.

Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S et al..  2014.  Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.. Cancer Discov. 4(9):1022-35.

Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S et al..  2014.  Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.. Cancer Discov. 4(9):1022-35.

Chiron D, Di Liberto M, Martin P, Huang X, Sharman J, Blecua P, Mathew S, Vijay P, Eng K, Ali S et al..  2014.  Cell-cycle reprogramming for PI3K inhibition overrides a relapse-specific C481S BTK mutation revealed by longitudinal functional genomics in mantle cell lymphoma.. Cancer Discov. 4(9):1022-35.

Jiang Y, Redmond D, Nie K, Eng KW, Clozel T, Martin P, Tan LHc, Melnick AM, Tam W, Elemento O.  2014.  Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.. Genome Biol. 15(8):432.

Jiang Y, Redmond D, Nie K, Eng KW, Clozel T, Martin P, Tan LHc, Melnick AM, Tam W, Elemento O.  2014.  Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.. Genome Biol. 15(8):432.

Erler P, Keutgen XM, Crowley MJ, Zetoune T, Kundel A, Kleiman D, Beninato T, Scognamiglio T, Elemento O, Zarnegar R et al..  2014.  Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.. Surgery. 156(6):1342-50;discussion1350.

Erler P, Keutgen XM, Crowley MJ, Zetoune T, Kundel A, Kleiman D, Beninato T, Scognamiglio T, Elemento O, Zarnegar R et al..  2014.  Dicer expression and microRNA dysregulation associate with aggressive features in thyroid cancer.. Surgery. 156(6):1342-50;discussion1350.

Prasain N, Lee MRyul, Vemula S, Meador JLuke, Yoshimoto M, Ferkowicz MJ, Fett A, Gupta M, Rapp BM, Saadatzadeh MReza et al..  2014.  Differentiation of human pluripotent stem cells to cells similar to cord-blood endothelial colony-forming cells.. Nat Biotechnol. 32(11):1151-1157.

Thakur BKumar, Zhang H, Becker A, Matei I, Huang Y, Costa-Silva B, Zheng Y, Hoshino A, Brazier H, Xiang J et al..  2014.  Double-stranded DNA in exosomes: a novel biomarker in cancer detection.. Cell Res. 24(6):766-9.

Kasap C, Elemento O, Kapoor TM.  2014.  DrugTargetSeqR: a genomics- and CRISPR-Cas9-based method to analyze drug targets.. Nat Chem Biol. 10(8):626-8.

Lu Y-C, Chang S-H, Hafner M, Li X, Tuschl T, Elemento O, Hla T.  2014.  ELAVL1 modulates transcriptome-wide miRNA binding in murine macrophages.. Cell Rep. 9(6):2330-43.

Chang S-H, Elemento O, Zhang J, Zhuang ZW, Simons M, Hla T.  2014.  ELAVL1 regulates alternative splicing of eIF4E transporter to promote postnatal angiogenesis.. Proc Natl Acad Sci U S A. 111(51):18309-14.

Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC et al..  2014.  Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.. PLoS Genet. 10(9):e1004566.

Popovic R, Martinez-Garcia E, Giannopoulou EG, Zhang Q, Zhang Q, Ezponda T, Shah MY, Zheng Y, Will CM, Small EC et al..  2014.  Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation.. PLoS Genet. 10(9):e1004566.

Wen D, Banaszynski LA, Liu Y, Geng F, Noh K-M, Xiang J, Elemento O, Rosenwaks Z, C Allis D, Rafii S.  2014.  Histone variant H3.3 is an essential maternal factor for oocyte reprogramming.. Proc Natl Acad Sci U S A. 111(20):7325-30.

de Martino M, Zhuang D, Klatte T, Rieken M, Rouprêt M, Xylinas E, Clozel T, Krzywinski M, Elemento O, Shariat SF.  2014.  Impact of ERBB2 mutations on in vitro sensitivity of bladder cancer to lapatinib.. Cancer Biol Ther. 15(9):1239-47.