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Found 22 results
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Author
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Melnick, Ari M
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V
Jiang Y
,
Nie K
,
Redmond D
,
Melnick AM
,
Tam W
,
Elemento O
. 2015.
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma.
.
J Vis Exp. (106):e53215.
U
Chu C-S
,
Hellmuth JC
,
Singh R
,
Ying H-Y
,
Skrabanek L
,
Teater MR
,
Doane AS
,
Elemento O
,
Melnick AM
,
Roeder RG
. 2020.
Unique Immune Cell Coactivators Specify Locus Control Region Function and Cell Stage.
.
Mol Cell. 80(5):845-861.e10.
T
Dominguez PM
,
Ghamlouch H
,
Rosikiewicz W
,
Kumar P
,
Béguelin W
,
Fontán L
,
Rivas MA
,
Pawlikowska P
,
Armand M
,
Mouly E
et al.
. 2018.
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
.
Cancer Discov. 8(12):1632-1653.
Venturutti L
,
Teater M
,
Zhai A
,
Chadburn A
,
Babiker L
,
Kim D
,
Béguelin W
,
Lee TC
,
Kim Y
,
Chin CR
et al.
. 2020.
TBL1XR1 Mutations Drive Extranodal Lymphoma by Inducing a Pro-tumorigenic Memory Fate.
.
Cell. 182(2):297-316.e27.
S
Park J
,
Foox J
,
Hether T
,
Danko D
,
Warren S
,
Kim Y
,
Reeves J
,
Butler DJ
,
Mozsary C
,
Rosiene J
et al.
. 2021.
Systemic Tissue and Cellular Disruption from SARS-CoV-2 Infection revealed in COVID-19 Autopsies and Spatial Omics Tissue Maps.
.
bioRxiv.
Rivas MA
,
Meydan C
,
Chin CR
,
Challman MF
,
Kim D
,
Bhinder B
,
Kloetgen A
,
Viny AD
,
Teater MR
,
McNally DR
et al.
. 2021.
Smc3 dosage regulates B cell transit through germinal centers and restricts their malignant transformation.
.
Nat Immunol. 22(2):240-253.
R
Cárdenas MG
,
Yu W
,
Béguelin W
,
Teater MR
,
Geng H
,
Goldstein RL
,
Oswald E
,
Hatzi K
,
Yang S-N
,
Cohen J
et al.
. 2016.
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
.
J Clin Invest. 126(9):3351-62.
O
Rickman DS
,
T Soong D
,
Moss B
,
Mosquera JMiguel
,
Dlabal J
,
Terry S
,
MacDonald TY
,
Tripodi J
,
Bunting K
,
Najfeld V
et al.
. 2012.
Oncogene-mediated alterations in chromatin conformation.
.
Proc Natl Acad Sci U S A. 109(23):9083-8.
M
Béguelin W
,
Teater M
,
Meydan C
,
Hoehn KB
,
Phillip JM
,
Soshnev AA
,
Venturutti L
,
Rivas MA
,
Calvo-Fernández MT
,
Gutierrez J
et al.
. 2020.
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
.
Cancer Cell. 37(5):655-673.e11.
Bunting KL
,
T Soong D
,
Singh R
,
Jiang Y
,
Béguelin W
,
Poloway DW
,
Swed BL
,
Hatzi K
,
Reisacher W
,
Teater M
et al.
. 2016.
Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region.
.
Immunity. 45(3):497-512.
I
Geng H
,
Brennan S
,
Milne TA
,
Chen W-Y
,
Li Y
,
Hurtz C
,
Kweon S-M
,
Zickl L
,
Shojaee S
,
Neuberg D
et al.
. 2012.
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.
.
Cancer Discov. 2(11):1004-23.
H
Ortega-Molina A
,
Boss IW
,
Canela A
,
Pan H
,
Jiang Y
,
Zhao C
,
Jiang M
,
Hu D
,
Agirre X
,
Niesvizky I
et al.
. 2015.
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
.
Nat Med. 21(10):1199-208.
Yusufova N
,
Kloetgen A
,
Teater M
,
Osunsade A
,
Camarillo JM
,
Chin CR
,
Doane AS
,
Venters BJ
,
Portillo-Ledesma S
,
Conway J
et al.
. 2021.
Histone H1 loss drives lymphoma by disrupting 3D chromatin architecture.
.
Nature. 589(7841):299-305.
G
Jiang Y
,
T Soong D
,
Wang L
,
Melnick AM
,
Elemento O
. 2012.
Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.
.
PLoS One. 7(7):e40332.
E
Velichutina I
,
Shaknovich R
,
Geng H
,
Johnson NA
,
Gascoyne RD
,
Melnick AM
,
Elemento O
. 2010.
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
.
Blood. 116(24):5247-55.
Béguelin W
,
Popovic R
,
Teater M
,
Jiang Y
,
Bunting KL
,
Rosen M
,
Shen H
,
Yang SNing
,
Wang L
,
Ezponda T
et al.
. 2013.
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
.
Cancer Cell. 23(5):677-92.
Béguelin W
,
Rivas MA
,
Fernandez MTCalvo
,
Teater M
,
Purwada A
,
Redmond D
,
Shen H
,
Challman MF
,
Elemento O
,
Singh A
et al.
. 2017.
EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop.
.
Nat Commun. 8(1):877.
Béguelin W
,
Teater M
,
Gearhart MD
,
Fernández MTeresa Cal
,
Goldstein RL
,
Cárdenas MG
,
Hatzi K
,
Rosen M
,
Shen H
,
Corcoran CM
et al.
. 2016.
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
.
Cancer Cell. 30(2):197-213.
Pan H
,
Jiang Y
,
Boi M
,
Tabbò F
,
Redmond D
,
Nie K
,
Ladetto M
,
Chiappella A
,
Cerchietti L
,
Shaknovich R
et al.
. 2015.
Epigenomic evolution in diffuse large B-cell lymphomas.
.
Nat Commun. 6:6921.
Lin P-C
,
Chiu Y-L
,
Banerjee S
,
Park K
,
Mosquera JMiguel
,
Giannopoulou E
,
Alves P
,
Tewari AK
,
Gerstein MB
,
Beltran H
et al.
. 2013.
Epigenetic repression of miR-31 disrupts androgen receptor homeostasis and contributes to prostate cancer progression.
.
Cancer Res. 73(3):1232-44.
D
Jiang Y
,
Redmond D
,
Nie K
,
Eng KW
,
Clozel T
,
Martin P
,
Tan LHc
,
Melnick AM
,
Tam W
,
Elemento O
. 2014.
Deep sequencing reveals clonal evolution patterns and mutation events associated with relapse in B-cell lymphomas.
.
Genome Biol. 15(8):432.
C
Jiang Y
,
Ortega-Molina A
,
Geng H
,
Ying H-Y
,
Hatzi K
,
Parsa S
,
McNally D
,
Wang L
,
Doane AS
,
Agirre X
et al.
. 2017.
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
.
Cancer Discov. 7(1):38-53.