Publications

Lin P-C, Giannopoulou EG, Park K, Mosquera JMiguel, Sboner A, Tewari AK, Garraway LA, Beltran H, Rubin MA, Elemento O.  2013.  Epigenomic alterations in localized and advanced prostate cancer.. Neoplasia. 15(4):373-83.

Béguelin W, Popovic R, Teater M, Jiang Y, Bunting KL, Rosen M, Shen H, Yang SNing, Wang L, Ezponda T et al..  2013.  EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.. Cancer Cell. 23(5):677-92.

Bödör C, Grossmann V, Popov N, Okosun J, O'Riain C, Tan K, Marzec J, Araf S, Wang J, Lee AM et al..  2013.  EZH2 mutations are frequent and represent an early event in follicular lymphoma.. Blood. 122(18):3165-8.

Hess ME, Hess S, Meyer KD, Verhagen LAW, Koch L, Brönneke HS, Dietrich MO, Jordan SD, Saletore Y, Elemento O et al..  2013.  The fat mass and obesity associated gene (Fto) regulates activity of the dopaminergic midbrain circuitry.. Nat Neurosci. 16(8):1042-8.

Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF.  2013.  Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.. Proc Natl Acad Sci U S A. 110(49):E4790-7.

Rafii S, Kloss CC, Butler JM, Ginsberg M, Gars E, Lis R, Zhan Q, Josipovic P, Ding B-S, Xiang J et al..  2013.  Human ESC-derived hemogenic endothelial cells undergo distinct waves of endothelial to hematopoietic transition.. Blood. 121(5):770-80.

Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM et al..  2013.  A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.. Cell Rep. 4(3):578-88.

Giannopoulou EG, Elemento O.  2013.  Inferring chromatin-bound protein complexes from genome-wide binding assays.. Genome Res. 23(8):1295-306.

Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, Karoly ED, Mohney R, Stiles BM, Elemento O, Altorki NK et al..  2013.  Metabolic alterations in lung cancer-associated fibroblasts correlated with increased glycolytic metabolism of the tumor.. Mol Cancer Res. 11(6):579-92.

Nolan DJ, Ginsberg M, Israely E, Palikuqi B, Poulos MG, James D, Ding B-S, Schachterle W, Liu Y, Rosenwaks Z et al..  2013.  Molecular signatures of tissue-specific microvascular endothelial cell heterogeneity in organ maintenance and regeneration.. Dev Cell. 26(2):204-19.

Chang C-Y, H Pasolli A, Giannopoulou EG, Guasch G, Gronostajski RM, Elemento O, Fuchs E.  2013.  NFIB is a governor of epithelial-melanocyte stem cell behaviour in a shared niche.. Nature. 495(7439):98-102.

Lu Y, T Soong D, Elemento O.  2013.  A novel approach for characterizing microsatellite instability in cancer cells.. PLoS One. 8(5):e63056.

Baca SC, Prandi D, Lawrence MS, Mosquera JMiguel, Romanel A, Drier Y, Park K, Kitabayashi N, MacDonald TY, Ghandi M et al..  2013.  Punctuated evolution of prostate cancer genomes.. Cell. 153(3):666-77.

Sun X-J, Wang Z, Wang L, Jiang Y, Kost N, T Soong D, Chen W-Y, Tang Z, Nakadai T, Elemento O et al..  2013.  A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis.. Nature. 500(7460):93-7.

Qiao Y, Giannopoulou EG, Chan CHin, Park S-H, Gong S, Chen J, Hu X, Elemento O, Ivashkiv LB.  2013.  Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.. Immunity. 39(3):454-69.

Keutgen XM, Buitrago D, Filicori F, Kundel A, Elemento O, Fahey TJ, Zarnegar R.  2012.  Calcimimetics versus parathyroidectomy for treatment of primary hyperparathyroidism: retrospective chart analysis of a prospective database.. Ann Surg. 255(5):981-5.

Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR.  2012.  Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons.. Cell. 149(7):1635-46.

Gollamudi S, Johri A, Calingasan NY, Yang L, Elemento O, M Beal F.  2012.  Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.. PLoS One. 7(5):e36191.

Ginsberg M, James D, Ding B-S, Nolan D, Geng F, Butler JM, Schachterle W, Pulijaal VR, Mathew S, Chasen ST et al..  2012.  Efficient direct reprogramming of mature amniotic cells into endothelial cells by ETS factors and TGFβ suppression.. Cell. 151(3):559-75.

Mason CE, Elemento O.  2012.  Faster sequencers, larger datasets, new challenges.. Genome Biol. 13(3):314.

Jiang Y, T Soong D, Wang L, Melnick AM, Elemento O.  2012.  Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphoma.. PLoS One. 7(7):e40332.

Demichelis F, Setlur SR, Banerjee S, Chakravarty D, Chen JYun Helen, Chen CX, Huang J, Beltran H, Oldridge DA, Kitabayashi N et al..  2012.  Identification of functionally active, low frequency copy number variants at 15q21.3 and 12q21.31 associated with prostate cancer risk.. Proc Natl Acad Sci U S A. 109(17):6686-91.

Geng H, Brennan S, Milne TA, Chen W-Y, Li Y, Hurtz C, Kweon S-M, Zickl L, Shojaee S, Neuberg D et al..  2012.  Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia.. Cancer Discov. 2(11):1004-23.

Rickman DS, T Soong D, Moss B, Mosquera JMiguel, Dlabal J, Terry S, MacDonald TY, Tripodi J, Bunting K, Najfeld V et al..  2012.  Oncogene-mediated alterations in chromatin conformation.. Proc Natl Acad Sci U S A. 109(23):9083-8.

Elemento O, Rubin MA, Rickman DS.  2012.  Oncogenic transcription factors as master regulators of chromatin topology: a new role for ERG in prostate cancer.. Cell Cycle. 11(18):3380-3.