| Title | Upper tract urothelial carcinoma has a luminal-papillary T-cell depleted contexture and activated FGFR3 signaling. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Robinson BD, Vlachostergios PJ, Bhinder B, Liu W, Li K, Moss TJ, Bareja R, Park K, Tavassoli P, Cyrta J, Tagawa ST, Nanus DM, Beltran H, Molina AM, Khani F, Mosquera JMiguel, Xylinas E, Shariat SF, Scherr DS, Rubin MA, Lerner SP, Matin SF, Elemento O, Faltas BM |
| Journal | Nat Commun |
| Volume | 10 |
| Issue | 1 |
| Pagination | 2977 |
| Date Published | 2019 07 05 |
| ISSN | 2041-1723 |
| Keywords | Aged, Aged, 80 and over, Carcinoma, Transitional Cell, DNA Mutational Analysis, Down-Regulation, Female, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Humans, Kidney Neoplasms, Male, Microsatellite Instability, Middle Aged, Mutation, Receptor, Fibroblast Growth Factor, Type 3, Sequence Analysis, RNA, Signal Transduction, T-Lymphocytes, Tumor Microenvironment, Ureteral Neoplasms, Urothelium, Whole Exome Sequencing |
| Abstract | Upper tract urothelial carcinoma (UTUC) is characterized by a distinctly aggressive clinical phenotype. To define the biological features driving this phenotype, we performed an integrated analysis of whole-exome and RNA sequencing of UTUC. Here we report several key insights from our molecular dissection of this disease: 1) Most UTUCs are luminal-papillary; 2) UTUC has a T-cell depleted immune contexture; 3) High FGFR3 expression is enriched in UTUC and correlates with its T-cell depleted immune microenvironment; 4) Sporadic UTUC is characterized by a lower total mutational burden than urothelial carcinoma of the bladder. Our findings lay the foundation for a deeper understanding of UTUC biology and provide a rationale for the development of UTUC-specific treatment strategies. |
| DOI | 10.1038/s41467-019-10873-y |
| Alternate Journal | Nat Commun |
| PubMed ID | 31278255 |
| PubMed Central ID | PMC6611775 |