Tracing the roots of cancer evolution.

TitleTracing the roots of cancer evolution.
Publication TypeJournal Article
Year of Publication2014
AuthorsJiang Y, Elemento O
JournalCancer Discov
Date Published2014 Sep
KeywordsHematopoietic Stem Cells, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Mutation

SUMMARY: By comparing the genomes of progenitor cells and mature cells of lymphoid and myeloid lineages in patients with chronic lymphocytic leukemia (CLL), Damm and colleagues confirmed that CLL originates from preleukemic CD34(+) progenitor cells and identified early CLL mutations that are associated with these progenitor cells. Moreover, they discovered that deregulation of B-cell receptor signaling may be one of the hallmarks of CLL, particularly in tumors with EGR2 mutations.

Alternate JournalCancer Discov
PubMed ID25185189
PubMed Central IDPMC4155509
Grant ListR01 CA104348 / CA / NCI NIH HHS / United States