Submitted by als2076 on August 12, 2020 - 10:18am
| Title | Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis. |
| Publication Type | Journal Article |
| Year of Publication | 2013 |
| Authors | Rath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF |
| Journal | Proc Natl Acad Sci U S A |
| Volume | 110 |
| Issue | 49 |
| Pagination | E4790-7 |
| Date Published | 2013 Dec 03 |
| ISSN | 1091-6490 |
| Keywords | Animals, Bacterial Proteins, Female, Host-Pathogen Interactions, Immunomodulation, Lipoproteins, Macrophages, Magnetic Resonance Spectroscopy, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Electron, Scanning, Models, Molecular, Mycobacterium tuberculosis, Protein Folding, Toll-Like Receptor 2, Transport Vesicles |
| Abstract | Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator." |
| DOI | 10.1073/pnas.1320118110 |
| Alternate Journal | Proc. Natl. Acad. Sci. U.S.A. |
| PubMed ID | 24248369 |
| PubMed Central ID | PMC3856836 |
| Grant List | R01 AI070285 / AI / NIAID NIH HHS / United States R01 AI70285 / AI / NIAID NIH HHS / United States |