Elemento Lab

Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.

Submitted by als2076 on August 12, 2020 - 10:18am
TitleGenetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis.
Publication TypeJournal Article
Year of Publication2013
AuthorsRath P, Huang C, Wang T, Wang T, Li H, Prados-Rosales R, Elemento O, Casadevall A, Nathan CF
JournalProc Natl Acad Sci U S A
Volume110
Issue49
PaginationE4790-7
Date Published2013 Dec 03
ISSN1091-6490
KeywordsAnimals, Bacterial Proteins, Female, Host-Pathogen Interactions, Immunomodulation, Lipoproteins, Macrophages, Magnetic Resonance Spectroscopy, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Microscopy, Electron, Scanning, Models, Molecular, Mycobacterium tuberculosis, Protein Folding, Toll-Like Receptor 2, Transport Vesicles
Abstract

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

DOI10.1073/pnas.1320118110
Alternate JournalProc. Natl. Acad. Sci. U.S.A.
PubMed ID24248369
PubMed Central IDPMC3856836
Grant ListR01 AI070285 / AI / NIAID NIH HHS / United States
R01 AI70285 / AI / NIAID NIH HHS / United States