Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.

TitleFast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach.
Publication TypeJournal Article
Year of Publication2005
AuthorsElemento O, Tavazoie S
JournalGenome Biol
Volume6
Issue2
PaginationR18
Date Published2005
ISSN1474-760X
KeywordsAnimals, Base Sequence, Caenorhabditis, Conserved Sequence, Drosophila, Genomics, Humans, Mice, Regulatory Elements, Transcriptional, Saccharomyces, Sequence Alignment, Time Factors
Abstract

We describe a powerful new approach for discovering globally conserved regulatory elements between two genomes. The method is fast, simple and comprehensive, without requiring alignments. Its application to pairs of yeasts, worms, flies and mammals yields a large number of known and novel putative regulatory elements. Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances.

DOI10.1186/gb-2005-6-2-r18
Alternate JournalGenome Biol.
PubMed ID15693947
PubMed Central IDPMC551538
Grant ListR56 HG003219 / HG / NHGRI NIH HHS / United States