Title | CATCH-KB: Establishing a Pharmacogenomics Variant Repository for Chemotherapy-Induced Cardiotoxicity. |
Publication Type | Journal Article |
Year of Publication | 2018 |
Authors | Morash M, Mitchell H, Yu A, Campion T, Beltran H, Elemento O, Pathak J |
Journal | AMIA Jt Summits Transl Sci Proc |
Volume | 2017 |
Pagination | 168-177 |
Date Published | 2018 |
ISSN | 2153-4063 |
Abstract | The Cardiotoxicity of Chemotherapy Knowledgebase (CATCH-KB) contains information extracted from articles investigating an association between germline genetic polymorphisms and the development of chemotherapy-induced cardiotoxicity (CIC) in cancer patients receiving antineoplastic treatments. CATCH-KB also contains integrated gene and drug information from open biomedical resources such as PharmGKB and SIDER. Furthermore, the genetic polymorphisms, drugs, and cancer types detailed in CATCH-KB are standardized according to appropriate biomedical ontologies, such as SNOMED-CT and RxNorm. CATCH-KB currently contains information on 49 research papers published between 2004 and 2017 investigating a total of 2,210 variants in over 280 genes for an association with CIC. By centralizing this information and linking it to external open-access biomedical resources, CATCH-KB will facilitate hypothesis generation and meta-analysis efforts and will ultimately accelerate the use of genetic screening in preventing CIC. CATCH-KB is publicly accessible via http://catchkb.org. |
Alternate Journal | AMIA Jt Summits Transl Sci Proc |
PubMed ID | 29888066 |
PubMed Central ID | PMC5961780 |
Grant List | R01 GM103859 / GM / NIGMS NIH HHS / United States R01 GM105688 / GM / NIGMS NIH HHS / United States |