Date Created: August 12, 2020 - 3:34pm
Position Summary
The Englander Institute for Precision Medicine at Weill Cornell Medicine is seeking a postdoctoral fellow with a background in cancer biology or a related field to join our team. We are seeking a dynamic individual who will be responsible for designing and executing studies focused on circulating tumor cells and organoid development.
A priority of the Englander Institute for Precision Medicine is to optimize and implement new innovative cancer tests that can be utilized to (i) identify cancer biomarkers in the circulating tumor cells that tell oncologists if a patient’s cancer is progressing and which therapies will be most effective for that patient (ii) develop targeted clinical trials for patients with highly recurrent mutations; and (iii) enhance scientists understanding of the complex mechanisms of tumor cell mobility. Our research is focused on the utilization of patient derived models of cancer, the definition of distinct molecular classes of cancer using genomic data from human samples, studying the functional impact of novel genetic and epigenetic alterations in preclinical models, and investigating the potential to translate these findings to clinical relevance.
The work will be performed under the supervision of Dr. Olivier Elemento, Director of Englander Institute for Precision Medicine. The candidate will collaborate with a multidisciplinary team composed of basic scientists, computational biologists, pathologists, and medical oncologists, with significant resources for bioinformatics support and studies in human tissues.
The candidate is expected to perform experiments exploring high-throughput drug screening platforms, organoid model development, tumor microenvironment, tumor metabolism, and genetic and epigenetic alterations using a variety of preclinical model systems including cell lines, xenografts, and genetically engineered mouse models. A desire to develop and implement new methodologies is highly advantageous. There will be numerous opportunities for training to complement current skills, and we envision numerous collaborations with other outstanding scientists.
Applicants should have experience in a related field, together with a strong publication record, and strong previous research experience in signal transduction, transcriptional control, genomics and bioinformatics, or related fields. Experience with several of the following activities would be desirable: characterization of genetically engineered mouse models, work with patient-derived xenografts and culture of primary cells. Initial salary is commensurate with experience. Applying for independent funding is not required, but is strongly encouraged for the career development of the candidate.
Job Responsibilities:
- Perform experiments exploring high-throughput drug screening platforms, organoid model development, tumor microenvironment, tumor metabolism, and genetic and epigenetic alterations using a variety of preclinical model systems including cell lines, xenografts, and genetically engineered mouse models.
Education:
Ph.D. in biological sciences, biochemistry or related field.
Experience:
- Minimum 2 years laboratory experience
- Strong publication record
- Driven and Self-motivated – Willingness to tackle and drive execution of challenging projects
- Ability to learn and deliver work in fast-paced and diverse environment
- Comfortable with communicating and working alongside a diverse team of scientists and medical professionals
- Preferred experience: characterization of genetically engineered mouse models, work with patient-derived xenografts and culture of primary cells
- Excellent organization and documentation skills
Knowledge, Skills and Abilities:
- Strong communication skills and an ability to interact well with others
- Detail-oriented
To Apply:
Interested candidates should forward their CV/resumes, with cover letter, to Theresa MacDonald (thm2008@med.cornell.edu).