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Found 15 results
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Author
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Shaknovich, Rita
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A
De S
,
Shaknovich R
,
Riester M
,
Elemento O
,
Geng H
,
Kormaksson M
,
Jiang Y
,
Woolcock B
,
Johnson N
,
Polo JM
et al.
. 2013.
Aberration in DNA methylation in B-cell lymphomas has a complex origin and increases with disease severity.
.
PLoS Genet. 9(1):e1003137.
Teater M
,
Dominguez PM
,
Redmond D
,
Chen Z
,
Ennishi D
,
Scott DW
,
Cimmino L
,
Ghione P
,
Chaudhuri J
,
Gascoyne RD
et al.
. 2018.
AICDA drives epigenetic heterogeneity and accelerates germinal center-derived lymphomagenesis.
.
Nat Commun. 9(1):222.
B
Ci W
,
Polo JM
,
Cerchietti L
,
Shaknovich R
,
Wang L
,
Yang SNing
,
Ye K
,
Farinha P
,
Horsman DE
,
Gascoyne RD
et al.
. 2009.
The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL.
.
Blood. 113(22):5536-48.
C
Jiang Y
,
Ortega-Molina A
,
Geng H
,
Ying H-Y
,
Hatzi K
,
Parsa S
,
McNally D
,
Wang L
,
Doane AS
,
Agirre X
et al.
. 2017.
CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas.
.
Cancer Discov. 7(1):38-53.
D
Dominguez PM
,
Teater M
,
Chambwe N
,
Kormaksson M
,
Redmond D
,
Ishii J
,
Vuong B
,
Chaudhuri J
,
Melnick A
,
Vasanthakumar A
et al.
. 2015.
DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
.
Cell Rep. 12(12):2086-98.
Shaknovich R
,
Geng H
,
Johnson NA
,
Tsikitas L
,
Cerchietti L
,
Greally JM
,
Gascoyne RD
,
Elemento O
,
Melnick A
. 2010.
DNA methylation signatures define molecular subtypes of diffuse large B-cell lymphoma.
.
Blood. 116(20):e81-9.
Shaknovich R
,
Cerchietti L
,
Tsikitas L
,
Kormaksson M
,
De S
,
Figueroa ME
,
Ballon G
,
Yang SNing
,
Weinhold N
,
Reimers M
et al.
. 2011.
DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.
.
Blood. 118(13):3559-69.
Sagardoy A
,
Martinez-Ferrandis JI
,
Roa S
,
Bunting KL
,
Aznar MAngela
,
Elemento O
,
Shaknovich R
,
Fontán L
,
Fresquet V
,
Perez-Roger I
et al.
. 2013.
Downregulation of FOXP1 is required during germinal center B-cell function.
.
Blood. 121(21):4311-20.
E
Pan H
,
Jiang Y
,
Boi M
,
Tabbò F
,
Redmond D
,
Nie K
,
Ladetto M
,
Chiappella A
,
Cerchietti L
,
Shaknovich R
et al.
. 2015.
Epigenomic evolution in diffuse large B-cell lymphomas.
.
Nat Commun. 6:6921.
Béguelin W
,
Teater M
,
Gearhart MD
,
Fernández MTeresa Cal
,
Goldstein RL
,
Cárdenas MG
,
Hatzi K
,
Rosen M
,
Shen H
,
Corcoran CM
et al.
. 2016.
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis.
.
Cancer Cell. 30(2):197-213.
Béguelin W
,
Popovic R
,
Teater M
,
Jiang Y
,
Bunting KL
,
Rosen M
,
Shen H
,
Yang SNing
,
Wang L
,
Ezponda T
et al.
. 2013.
EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation.
.
Cancer Cell. 23(5):677-92.
Velichutina I
,
Shaknovich R
,
Geng H
,
Johnson NA
,
Gascoyne RD
,
Melnick AM
,
Elemento O
. 2010.
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis.
.
Blood. 116(24):5247-55.
H
Ortega-Molina A
,
Boss IW
,
Canela A
,
Pan H
,
Jiang Y
,
Zhao C
,
Jiang M
,
Hu D
,
Agirre X
,
Niesvizky I
et al.
. 2015.
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development.
.
Nat Med. 21(10):1199-208.
R
Cárdenas MG
,
Yu W
,
Béguelin W
,
Teater MR
,
Geng H
,
Goldstein RL
,
Oswald E
,
Hatzi K
,
Yang S-N
,
Cohen J
et al.
. 2016.
Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma.
.
J Clin Invest. 126(9):3351-62.
T
Dominguez PM
,
Ghamlouch H
,
Rosikiewicz W
,
Kumar P
,
Béguelin W
,
Fontán L
,
Rivas MA
,
Pawlikowska P
,
Armand M
,
Mouly E
et al.
. 2018.
TET2 Deficiency Causes Germinal Center Hyperplasia, Impairs Plasma Cell Differentiation, and Promotes B-cell Lymphomagenesis.
.
Cancer Discov. 8(12):1632-1653.